![]() ![]() ![]() TETRA delivers proven mission critical communications and is trusted to deliver it cost effectively. That is why you’ll find TETRA technology deployed in over 100 countries, supporting Police, Emergency Medical and Fire and Rescue Services as well as utility companies, rail and metro lines, power stations, oil refineries and chemical plants. ![]() TETRA technologies enable every industry to have safe and reliable communications. The effectiveness, reliability and security of TETRA combined with its range of applications, makes it the primary means of communication for many businesses and organisations. TETRA infrastructures, devices, services and applications are used by many industries, including Public Safety, Oil & Gas, Transport and Logistics, Utilities and more. The formulation shows enhanced in vivo targeting ability relative to a formulation employing a scrambled control peptide, and significant ( P < 0.05) therapeutic efficacy relative to free SN-38 in the GBM xenograft animal model.TETRA systems are used in both public safety and commercial sectors by organisations that need reliability, capacity and security for their communications. Feasibility as a targeting agent for therapeutics is demonstrated in a GBM xenograft mouse model, where porous silicon nanoparticles (pSiNPs) containing the clinically relevant anticancer drug SN-38 are grafted with SIWV via a poly-(ethylene glycol) (PEG) linker. The mechanism of intracellular permeation is proposed to follow a caveolin-mediated endocytotic pathway, based on in vitro and in vivo receptor inhibition and genetic knockdown studies. The SIWV sequence was identified from an isoform of annexin-A3 (AA3H), a membrane-interacting human protein. Herein, we describe a new CPP (amino acid sequence serine-isoleucine-tyrosine-valine, or SIWV) that homes to glioblastoma multiforme (GBM) brain tumor tissues with remarkable specificity in vitro and in vivo. Organ-specific cell-penetrating peptides (CPPs) are a class of molecules that can be highly effective at delivering therapeutic cargoes, and they are currently of great interest in cancer treatment strategies. R&D Division of Drug Discovery Department, SPARK Biopharma, Seoul 08791, Republic of Korea Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea Herein, we describe a new CPP (amino acid sequence serine-isoleucine-tyrosine-valine, or SIWV) that Nanoscale Horizons 2021 Lunar New Year Collection. Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 03080, Republic of Koreaĭepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USAĭepartment of Otorhinolaryngology, Head & Neck Surgery, Kyung Hee University, Seoul 02447, Republic of KoreaĮ-mail: of Oriental Pharmaceutical Science and Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of KoreaĮ-mail: of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of KoreaĬenter for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea Laboratory of Vitamin C and Antioxidant Immunology, Department of Anatomy and Cell Biology, Seoul National University, College of Medicine, Seoul 03080, Republic of Korea Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of KoreaĮ-mail: for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Koreaĭepartment of Medical Science of Meridian, Graduate School, Kyung Hee University, Seoul 02447, Republic of Koreaĭepartment of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Koreaĭepartment of Biological Chemistry, Korea University of Science and Technology, KIST campus, Seoul 02792, Republic of Korea ![]()
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